| Challenger Surbiton | 06/07 11:10 | 26 | [107] Mackenzie McDonald v Matthew Ebden [73] | 3-6,7-6,3-6 | |
| Challenger Surbiton | 06/05 16:10 | 25 | [73] Matthew Ebden v Dustin Brown [149] | 6-7,7-5,6-3 | |
| Challenger Surbiton Qual | 06/04 10:00 | 54 | [73] Matthew Ebden v Max Purcell [216] | 7-6,6-0 | |
| Challenger Surbiton Qual | 06/03 11:15 | 46 | Matthew Ebden v Dayne Kelly | Retired | |
| French Open | 05/28 14:25 | 23 | [73] Matthew Ebden v Thomas Fabbiano [115] | 4-6,7-5,2-6,6-3,2-6 | |
| ATP Lyon | 05/22 10:35 | 25 | [70] Taylor Fritz v Matthew Ebden [73] | 6-4,6-2 | |
| Challenger Busan | 05/20 04:20 | 29 | [85] Matthew Ebden v Vasek Pospisil [78] | 7-6,6-1 | |
| Challenger Busan | 05/19 05:40 | 28 | [85] Matthew Ebden v Filip Peliwo [188] | 6-3,6-1 | |
| Challenger Busan | 05/18 05:35 | 27 | [85] Matthew Ebden v Jason Jung [152] | 6-2,6-2 | |
| Challenger Busan | 05/17 04:50 | 26 | [85] Matthew Ebden v Tatsuma Ito [160] | Retired | |
| Challenger Busan | 05/15 03:25 | 25 | [85] Matthew Ebden v Yunseong Chung [464] | 6-3,3-6,6-3 | |
| Challenger Gimcheon | 05/08 02:00 | 25 | [83] Matthew Ebden v Zhe Li [334] | Retired | |
| Challenger Taipei | 04/12 11:45 | 26 | [77] Matthew Ebden v Jason Jung [157] | 2-6,6-7 | |
| Challenger Taipei | 04/10 05:40 | 25 | [77] Matthew Ebden v Tsung-Hua Yang [251] | 6-3,6-4 | |
| ATP Miami | 03/23 20:20 | 24 | [23] Hyeon Chung v Matthew Ebden [76] | 6-3,7-5 | |
| ATP Miami | 03/21 17:45 | 23 | [76] Matthew Ebden v Gilles Simon [72] | 6-3,6-7,7-5 | |
| Challenger Irving | 03/13 18:00 | 25 | Mikhail Youzhny v Matthew Ebden | 3-6,6-1,7-6 | |
| ATP Indian Wells | 03/09 19:00 | 23 | Gael Monfils v Matthew Ebden | 6-3,6-3 | |
| ATP Acapulco | 02/28 22:00 | 26 | Jared Donaldson v Matthew Ebden | 6-3,6-1 | |
| ATP Acapulco | 02/27 22:00 | 25 | Matthew Ebden v Sam Querrey | 6-3,1-6,7-6 | |
| ATP Delray Beach | 02/19 23:00 | 25 | Matthew Ebden v Frances Tiafoe | 2-6,6-2,2-6 | |
| ATP New York | 02/14 00:15 | 25 | Mikhail Youzhny v Matthew Ebden | 3-6,6-3,6-4 | |
| Australian Open | 01/17 10:05 | 24 | Alexandr Dolgopolov v Matthew Ebden | 7-6,6-3,6-4 | |
| Australian Open | 01/15 02:20 | 23 | Matthew Ebden v John Isner | 6-4,3-6,6-3,6-3 | |
| Kooyong Classic | 01/12 00:00 | 1 | Pablo Carreno Busta v Matthew Ebden | 6-7,6-4,6-2 | |
| Kooyong Classic | 01/11 00:00 | 1 | Matthew Ebden v Richard Gasquet | 4-6,6-7 | |
| Kooyong Classic | 01/10 00:00 | 1 | Marin Čilić v Matthew Ebden | 7-6,4-6,5-7 | |
| ATP Brisbane | 01/03 04:25 | 26 | Nick Kyrgios v Matthew Ebden | 6-7,7-6,6-2 | |
| ATP Brisbane | 01/01 02:50 | 25 | Frances Tiafoe v Matthew Ebden | 3-6,2-6 | |
| Challenger Hua Hin | 11/24 11:25 | 27 | [80] Matthew Ebden v Go Soeda [166] | 4-6,5-7 |