Stadium: Roy Stewart Stadium Round: 1
Home Manager: Mitch Stewart Away Manager: Tom Matukewicz
| NCAAF FCS | 2018/11/03 18:00 | Tennessee State v SE Missouri St | W | 21-38 |
| NCAAF | 2018/10/27 19:00 | Tennessee Martin v SE Missouri St | W | 33-56 |
| NCAAF | 2018/10/20 18:00 | SE Missouri St v Jacksonville State | W | 37-14 |
| NCAAF | 2018/10/13 18:00 | Austin Peay v SE Missouri St | W | 27-31 |
| NCAAF | 2018/10/06 23:00 | SE Missouri St v Tennessee Tech University | W | 70-38 |
| NCAAF | 2018/09/22 20:00 | SE Missouri St v Eastern Kentucky | L | 14-23 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | W | 48-44 |
| NCAAF | 2018/09/08 18:00 | Dayton v SE Missouri St | W | 21-40 |
| NCAAF FCS | 2018/11/03 18:30 | Murray State v Tennessee Tech University | L | 24-27 |
| NCAAF | 2018/10/27 20:00 | Murray State v Jacksonville State | L | 15-42 |
| NCAAF | 2018/10/20 19:00 | Eastern Kentucky v Murray State | W | 6-34 |
| NCAAF | 2018/10/13 18:00 | Tennessee State v Murray State | W | 21-45 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | W | 48-41 |
| NCAAF | 2018/09/29 23:00 | Tennessee Martin v Murray State | W | 38-45 |
| NCAAF | 2018/09/15 16:00 | Murray State v Kentucky | L | 10-48 |
| NCAAF | 2018/09/08 23:00 | Murray State v Central Arkansas | L | 13-26 |