Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Tom Matukewicz
| NCAAF | 2018/09/08 18:00 | Dayton v SE Missouri St | W | 21-40 |
| NCAAF | 2018/09/01 23:00 | SE Missouri St v Arkansas State | L | 21-48 |
| NCAAF | 2017/11/18 19:00 | SE Missouri St v Murray State | W | 21-10 |
| NCAAF | 2017/11/11 20:00 | Tennessee State v SE Missouri St | L | 23-20 |
| NCAAF | 2017/11/04 18:00 | SE Missouri St v Tennessee Martin | L | 14-16 |
| NCAAF | 2017/10/28 20:00 | Jacksonville State v SE Missouri St | L | 23-7 |
| NCAAF | 2017/10/21 21:00 | Austin Peay v SE Missouri St | L | 38-31 |
| NCAAF | 2017/10/14 18:00 | SE Missouri St v Tennessee Tech University | W | 31-3 |
| NCAAF | 2018/09/08 20:00 | SO Illinois v Mississippi | L | 41-76 |
| NCAAF | 2018/08/30 23:00 | SO Illinois v Murray State | W | 49-10 |
| NCAAF | 2017/11/18 19:00 | Western Illinois v SO Illinois | L | 28-14 |
| NCAAF | 2017/11/11 19:00 | SO Illinois v Youngstown State | L | 20-28 |
| NCAAF | 2017/11/04 18:00 | SO Illinois v Missouri St | L | 28-36 |
| NCAAF | 2017/10/28 20:00 | South Dakota v SO Illinois | L | 42-0 |
| NCAAF | 2017/10/21 19:00 | Indiana State v SO Illinois | W | 24-45 |
| NCAAF | 2017/10/14 19:00 | SO Illinois v Illinois State | W | 42-7 |