Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2022/11/05 19:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 38-22 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2019/09/28 17:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 42-7 |
| NCAAF | 2023/10/28 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 49-18 |
| NCAAF | 2023/10/21 18:00 | Virginia Wise Highland Cavaliers v Erskine Flying Fleet | W | 34-23 |
| NCAAF | 2023/10/14 18:00 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | L | 35-7 |
| NCAAF | 2023/10/07 18:00 | Virginia Wise Highland Cavaliers v Emory And Henry Wasps | L | 24-41 |
| NCAAF | 2023/09/30 18:00 | Lenoir Rhyne Bears v Virginia Wise Highland Cavaliers | L | 56-3 |
| NCAAF | 2023/09/23 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 17-38 |
| NCAAF | 2023/09/16 20:00 | Barton Bulldogs v Virginia Wise Highland Cavaliers | L | 28-24 |
| NCAAF | 2023/09/09 16:00 | Thomas More Saints v Virginia Wise Highland Cavaliers | L | 37-0 |
| NCAAF | 2023/10/28 19:00 | Carson–Newman Eagles v Emory And Henry Wasps | W | 37-7 |
| NCAAF | 2023/10/21 17:00 | Carson–Newman Eagles v Mars Hill Lions | L | 17-21 |
| NCAAF | 2023/10/14 20:00 | Erskine Flying Fleet v Carson–Newman Eagles | W | 10-14 |
| NCAAF | 2023/10/07 17:00 | Carson–Newman Eagles v Tusculum Pioneers | L | 21-27 |
| NCAAF | 2023/09/30 22:00 | Newberry Wolves v Carson–Newman Eagles | W | 21-34 |
| NCAAF | 2023/09/23 17:00 | Carson–Newman Eagles v Lenoir Rhyne Bears | L | 7-24 |
| NCAAF | 2023/09/16 16:00 | Limestone Saints v Carson–Newman Eagles | L | 45-14 |
| NCAAF | 2023/09/09 21:30 | East Tennessee State v Carson–Newman Eagles | L | 42-0 |