Stadium: UPMC Cooper Fieldhouse
Home Manager: Keith Dambrot Away Manager: Speedy Claxton
| NCAAB | 2021/11/10 01:00 | Hofstra University v Houston | L | 75-83 |
| NCAAB | 2021/03/08 23:00 | Elon v Hofstra University | L | 76-58 |
| NCAAB | 2021/03/07 16:00 | Delaware v Hofstra University | W | 75-83 |
| NCAAB | 2021/02/14 19:00 | Hofstra University v James Madison | L | 70-74 |
| NCAAB | 2021/02/13 19:00 | Hofstra University v James Madison | L | 89-93 |
| NCAAB | 2021/02/07 19:00 | Drexel v Hofstra University | W | 74-79 |
| NCAAB | 2021/02/06 19:00 | Drexel v Hofstra University | L | 73-71 |
| NCAAB | 2021/01/31 18:00 | Hofstra University v UNC Wilmington | W | 89-83 |
| NCAAB | 2021/11/10 00:00 | Rider v Duquesne | W | 61-73 |
| NCAAB | 2021/03/05 16:00 | Duquesne v St. Bonaventure | L | 59-75 |
| NCAAB | 2021/03/04 16:00 | Duquesne v Richmond | W | 67-62 |
| NCAAB | 2021/02/28 00:00 | University of Rhode Island v Duquesne | W | 75-86 |
| NCAAB | 2021/02/25 00:00 | Duquesne v La Salle | L | 65-85 |
| NCAAB | 2021/02/20 21:30 | Duquesne v Richmond | L | 72-79 |
| NCAAB | 2021/02/03 02:00 | Dayton v Duquesne | W | 64-69 |
| NCAAB | 2021/01/31 00:00 | St Josephs v Duquesne | W | 50-67 |