[5] BUF Sabres 2-3 PIT Penguins [7] 2021-12-18 00:00
Stadium: PPG Paints Arena
Home Manager: Mike Sullivan Away Manager: Don Granato
Head to Head
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
| NHL - předsezóna | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL - předsezóna | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | W | 2-4 |
| NHL | 2021/04/17 19:00 | PIT Penguins v BUF Sabres | L | 3-2 |
| NHL | 2021/03/25 23:00 | BUF Sabres v PIT Penguins | L | 0-4 |
Home History
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
| NHL | 2021/12/15 01:00 | BUF Sabres v WIN Jets | W | 4-2 |
| NHL | 2021/12/12 00:00 | WAS Capitals v BUF Sabres | L | 3-2 |
| NHL | 2021/12/11 00:00 | NY Rangers v BUF Sabres | L | 2-1 |
| NHL | 2021/12/08 00:30 | ANA Ducks v BUF Sabres | L | 2-0 |
| NHL | 2021/12/05 00:30 | BUF Sabres v CAR Hurricanes | L | 2-6 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2021/11/30 00:00 | SEA Kraken v BUF Sabres | L | 7-4 |
Away History
| NHL | 2021/12/15 00:00 | MON Canadiens v PIT Penguins | W | 2-5 |
| NHL | 2021/12/12 00:00 | ANA Ducks v PIT Penguins | W | 0-1 |
| NHL | 2021/12/11 00:00 | PIT Penguins v WAS Capitals | W | 4-2 |
| NHL | 2021/12/07 03:00 | PIT Penguins v SEA Kraken | W | 6-1 |
| NHL | 2021/12/05 03:00 | PIT Penguins v VAN Canucks | W | 4-1 |
| NHL | 2021/12/02 03:00 | PIT Penguins v EDM Oilers | L | 2-5 |
| NHL | 2021/11/30 02:00 | PIT Penguins v CAL Flames | L | 1-2 |
| NHL | 2021/11/28 00:00 | MON Canadiens v PIT Penguins | L | 6-3 |
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